cardiology

Acute pericarditis

Overview Pericarditis refers to inflammation of the lining of the heart known as the pericardium. Inflammation of the pericardium can be acute or chronic: Acute pericarditis: acute-onset chest pain and characteristic ECG features (e.g. saddle ST elevation). Multiple aetiologies. Self-limiting without significant complications in 70-90% of cases. Chronic pericarditis: long-standing inflammation (> 3 months), usually follows acute episode. Complications include chronic pericardial effusion and constrictive pericarditis due to scarring. Acute pericarditis is the most common pericardial disease. Although true incidence is difficult to quantify, acute pericarditis is estimated to be present in 1% of adults who present with ST elevation changes on

Antiarrhythmics

Vaughan-William’s classification Anti-arrhythmics are drugs that modify cardiac conduction, they are used to treat arrhythmias and are classified according to the Vaughan-William’s system. This classification divides these drugs into four classes according to their effects on cardiac action potential. Anti-arrhythmics have complex actions and classes may overlap. It is important to note, that this classification system has become increasingly inadequate with improved understandings of drug mechanisms and development of new antiarrhythmics.     Arrhythmogenesis To understand the action of the antiarrhythmics it helps to understand how arrhythmias may develop. Arrhythmias are disorders of rate and rhythm of the heart, which

Acute coronary syndrome

Overview Acute coronary syndrome (ACS) refers to three states of myocardial ischaemia: unstable angina (UA), non-ST elevation myocardial infarction (NSTEMI) and ST elevation myocardial infarction (STEMI). ACS is a medical emergency requiring urgent admission. Around 100,000 people are admitted with ACS in the UK each year. Atherosclerosis represents the most significant aetiological factor. Classification ACS is classified into one of three conditions according to clinical features, ECG findings and cardiac enzymes: STEMI: ST-segment elevation or new-onset left bundle branch block and raised troponins. NSTEMI: Non-specific signs of ischaemia or normal ECG, raised troponins. UA: Characteristic clinical features, non-specific signs of