Amyloidosis

Overview Amyloidosis refers to the extracellular deposition of fibrils that contain a variety of proteins. An amyloid fibril is simply the assembly of insoluble protein fibres that are composed in a way that is resistant to degradation. This composition is known as a beta-pleated sheet. These deposits of amyloid fibrils are extracellular (i.e. occurring outside of cells) and may be seen in different tissues and organs. Hepatic amyloid. Seen as amorphous, acellular pink material on H&E stain The problem with amyloid is that deposition in tissue can lead to organ dysfunction. When organ dysfunction is caused by amyloid we usually