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Anti-biotics pharmacology

Which structure of the microorganism is affected by cephalosporins:
A. ribosome
B. cell wall
C. nucleus
D. mitochondria
E. vacuoles

Correct answer is :
Cell wall

Which side effect is characteristic for aminoglycosides:
A. nephrotoxicity
B. vestibulopathies
C. neuromuscular blockade
D. cochleatoxicity
E. all of the above

Correct answer is :
All listed side effects are characteristics for aminoglycosides

Which antibiotic is characterized by the penicillin type of resistance development:
A. erythromycin
B. tetracycline
C. rifampicin
D. gentamicin
E. cefazolin

Correct answer is :
Cefazolin

The metabolic rate of theophylline is altered when used concomitantly with which antibiotic:
A. doxycycline
B. cefazolin
C. erythromycin
D. gentamicin
E. penicillin

Correct answer is :
Erythromycin

Which group of antibiotics more often causes allergic reactions:
A. aminoglycosides
B. macrolides
C. penicillins
D. sulfonamides
E. lincosamines

Correct answer is :
Penicillins

Which antibiotic is degraded by b – lactamases:
A. ampicillin
B. gentamicin
C. tetracycline
D. ciprofloxacin
E. lincomycin

Correct answer is :
Ampicillin

Which side effect is characteristic of lincomycin:
A. anemia
B. hearing loss
C. polyneuritis
D. enterocolitis
E. azotemia

Correct answer is :
Enterocolitis

Name an antibiotic to treat susceptible strains of Streptococcus pneumoniae in the treatment of pneumonia:
A. ciprofloxacin
B. gentamicin
C. cefotaxime
D. doxycycline
E. tetracycline

Correct answer is :
Cefotaxime

Which antibiotic should be prescribed to affect b – lactamase-producing microorganisms:
A. penicillin
B. ampicillin
C. cefazolin
D. amoxiclav
E. amoxicillin

Correct answer is :
Amoxiclav

Choose an antibacterial agent to treat pneumonia caused by Mycoplasma pneumoniae:
A. lincosamides
B. penicillins
C. cephalosporins
D. macrolides
E. aminoglycosides

Correct answer is :
Macrolides

Mark the most appropriate combination of antibiotics for severe community-acquired pneumonia:
A. penicillins + aminoglycosides
B. aminoglycosides + second-generation cephalosporins
C. 3rd generation cephalosporins + macrolides
D. fluoroquinolones + aminoglycosides
E. macrolides + fluoroquinolones

Correct answer is :
3rd generation cephalosporins + macrolides

Which antibiotic has bactericidal action in high concentrations and bacteriostatic action in low concentrations:
A. penicillin
B. erythromycin
C. cefotaxime
D. gentamicin
E. lincomycin

Correct answer is :
Erythromycin

Which antibiotic is bactericidal:
A. tetracycline
B. lincomycin
C. chloramphenicol (levomycetin)
D. amikacin
E. erythromycin

Correct answer is :
Amikacin

The dosing regimen of which antibiotic should be changed in cases of renal failure:
A. ceftriaxone
B. gentamicin
C. doxycycline
D. erythromycin
E. cefoperazone

Correct answer is :
Gentamicin

Which of the following antibiotics should not be prescribed for cholestatic hepatitis:
A. erythromycin
B. ampicillin
C. claforan
D. lincomycin
E. ceftriaxone

Correct answer is :
Erythromycin

Which antibiotic requires correction of the administration regimen for hepatic insufficiency:
A. ampicillin
B. cefoperazone
C. imipenem
D. gentamicin
E. ciprofloxacin

Correct answer is :
Cefoperazone

Which antibiotic creates high concentrations in bone tissue:
A. gentamicin
B. nalidixic acid
C. lincomycin
D. erythromycin
E. cefatoxime

Correct answer is :
Lincomycin

Which side effect is not characteristic for ampicillin:
A. rash
B. allergic reactions
C. diarrhea
D. vaginal candidiasis
E. nephrotoxicity

Correct answer is :
Nephrotoxicity

Choose the safest antibiotic to treat a pregnant woman:
A. ampicillin
B. gentamicin
C. ciprofloxacin
D. levomycetin
E. biseptol

Correct answer is :
Ampicillin

Which antibiotic should preferably not be prescribed to the elderly:
A. penicillin
B. cefazolin
C. gentamicin
D. azithromycin
E. all of the above

Correct answer is :
Gentamicin

What is the advantage of carbapenems over other b – lactam antibiotics:
A. have 2 pathways of elimination
B. do not cause allergic reactions
C. are able to cross the blood-brain barrier
D. resistant to b-lactamases (ESBL) action
E. active against MRSA

Correct answer is :
Resistant to b-lactamases (ESBL) action

Why is imipenem used in combination with cilastatin:
A. to create therapeutic concentrations of the antibiotic in the urine
B. for better penetration of imipenem into tissues
C. for inhibition of B-lactamases of microbial cell
D. for obtaining a potentiating effect
E. for post-antibiotic effect

Correct answer is :
To create therapeutic concentrations of the antibiotic in the urine

Choose a drug to treat sepsis caused by MRSA:
A. ampicillin
B. cefazolin
C. thienam
D. azithromycin
E. linezolid

Correct answer is :
Linezolid

Select the most effective antipseudomonal drug:
A. amoxicillin
B. cefotaxime
C. imipenem
D. meropenem
E. gentamicin

Correct answer is :
Meropenem

Choose a cephalosporin for stepwise antibiotic therapy:
A. cefuroxime
B. ceftazidime
C. cefotaxime
D. cefipime
E. ceftriaxone

Correct answer is :
Cefuroxime

Mark the antipseudomonal cephalosporin:
A. cefazolin
B. cefotaxime
C. ceftripaxone
D. ceftazidime
E. cefaclor

Correct answer is :
Ceftazidime

Select an antibiotic from the lipopeptide group:
A. piperacillin
B. tigecycline
C. daptomycin
D. polymyxin M
E. ertapenem

Correct answer is :
Daptomycin

Mark the carbapenem without antisynegic activity:
A. ertapenem
B. meropenem
C. doripenem
D. imipenem
E. all of the above

Correct answer is :
Ertapenem

Which group of antibiotics includes tigecycline:
A. penicillins
B. tetracyclines
C. cephalosporins
D. fluoroquinolones
E. monobactams

Correct answer is :
Tetracyclines

Choose an antibiotic during the treatment with which alcohol should be excluded:
A. azithromycin
B. levofloxacin
C. lincomycin
D. cefoperazone
E. penicillin

Correct answer is :
Cefoperazone

Choose an antibiotic to treat tonsillitis caused by group A b-haemolytic streptococcus:
A. amikacin
B. ciprofloxacin
C. ceftazidime
D. tetracycline
E. amoxicillin

Correct answer is :
Amoxicillin

Choose an antispseudomonal penicillin:
A. ticarcillin
B. ampicillin
C. amoxicillin
D. azithromycin
E. tobramycin

Correct answer is :
Ticarcillin

Choose a drug to treat pseudomembranous colitis caused by C. difficile:
A. penicillin
B. cefotaxime
C. thienam
D. vancomycin
E. clarithromycin

Correct answer is :
Vancomycin

Choose a drug to treat an infection caused by MRSA:
A. cefazolin
B. amoxicillin/clavulanate
C. imipenem
D. azithromycin
E. vancomycin

Correct answer is :
Vancomycin

Select a fluoroquinolone with anti-anaerobic activity:
A. moxifloxacin
B. levofloxacin
C. ciprofloxacin
D. sparfloxacin
E. norfloxacin

Correct answer is :
Moxifloxacin

Choose the cephalosporin with the longest half-life:
A. cefazolin
B. cefuroxime
C. cefotaxime
D. ceftriaxone
E. cefepime

Correct answer is :
Ceftriaxone

Select an antibiotic that has a disulfiram-like effect:
A. cefazolin
B. clarithromycin
C. gentamicin
D. cefoperazone
E. ciprofloxacin

Correct answer is :
Cefoperazone

Which antibiotic causes hypoprothrombinemia:
A. cefotaxime
B. amoxicillin
C. azithromycin
D. cefoperazone
E. gentamicin

Correct answer is :
Cefoperazone

Choose a drug with proven antiinfluenza efficacy:
A. zanamivir
B. influenzaferon
C. dibasol
D. amixin
E. all of the above

Correct answer is :
Zanamivir

Which class of antiviral drugs oseltamivir (tamiflu) belongs to:
A. anti-herpetic
B. antiretroviral
C. anti-influenza
D. anticytomegaloviral
E. broad-spectrum

Correct answer is :
Anti-influenza

Choose an anti-herpetic drug:
A. remantadine
B. zanamivir
C. acyclovir
D. oseltamivir
E. arbidol

Correct answer is :
Acyclovir

Select the macrolide most active against Haemophilus influenzae:
A. azithromycin
B. erythromycin
C. roxithromycin
D. jozamycin
E. equal activity for all macrolides

Correct answer is :
Azithromycin

Select a macrolide that has parenteral forms:
A. clarithromycin
B. rovamycin
C. azithromycin
D. erythromycin
E. all of the above

Correct answer is :
All listed antibiotics are correct

Select the combination of antibiotics that increases the risk of cardiotoxicity ( prolongation of QT):
A. cephalosporins + macrolides
B. cephalosporins + aminoglycosides
C. fluoroquinolones + cephalosporins
D. fluoroquinolones + macrolides.
E. penicillins + macrolides

Correct answer is :
Fluoroquinolones + Macrolides

Choose a fluoroquinolone with antipseudomonal activity:
A. norfloxacin
B. lomifloxacin
C. sparfloxacin
D. levofloxacin
E. all of the above

Correct answer is :
All listed antibiotics are correct

Which antimicrobial drug is contraindicated in children:
A. penicillin
B. ceftriaxone
C. azithromycin
D. ciprofloxacin
E. erythromycin

Correct answer is :
Ciprofloxacin

Which drug is classified as a “respiratory” fluoroquinolone:
A. ciprofloxacin
B. ofloxacin
C. norfloxacin
D. levofloxacin
E. lomefloxacin

Correct answer is :
Levofloxacin

Which type of interaction occurs when gentamicin and penicillin are mixed in the same syringe:
A. pharmacodynamic
B. pharmacokinetic
C. pharmaceutical
D. physiological
E. no interaction

Correct answer is :
Pharmaceutical interaction

What is the recommended course of administration of aminoglycosides to reduce the risk of adverse reactions:
A. 4-5 days
B. 7-10 days
C. up to 2 weeks
D. up to 3 weeks
E. Up to 1 month