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- Which one of the following drugs is associated with the development of a lupus-like syndrome, especially in patients identified as “slow acetylators”?
- Arniodarone
- Clonidine
- Nitroglycerin
- Procainamide
- Terazosin
- Which one of the following actions is characteristic of amiloride?
- Alkalosis
- Block of Na reabsorption in the proximal tubule
- Hyperkalemia
- Increased tubular reabsorption of Ca
- Bicarbonaturia
- The most common manifestation of lidocaine toxicity is
- CNS dysfunction
- drug fever
- hypertension
- hypokalemia
- torsade
- A patient with hyperthyroidism develops a cardiac arrhythmia. Optimal treatment of the patient should include management with
- amiodarone
- bretylium
- digoxin
- lidocaine
- propranolol
- Calcium channel antagonists
- increase intracellular CAMP
- decrease myocardial contractility
- increase reactivation of Na channels
- decrease intracellular K
- increase conduction velocity
- In terms of the ability of drugs like digoxin to increase cardiac contractility, their primary action on cardiac cells is
- activation of adenylyl cyclase
- inactivation of Na channels
- activation of the slow Ca channel
- inhibition of NaIK-ATPase
- activation of the NaIC1 cotransporter
- Which one of the following drugs is most likely to block K+ channels in the heart responsible for the delayed rectifier current?
- Amiodarone
- Encainide
- Lidocaine
- Phenytoin
- Verapamil
- The treatment of hyperlipidemic patients with nicotinic acid (niacin) results in
- increases in VLDL
- decreases in both plasma cholesterol and TGs
- inhibition of HMG-CoA reductase
- decreases in HDL
- no change in total cholesterol in the plasma
- Following a myocardial infarction, a patient in the emergency room of a hospital develops ventricular tachycardia. The best way to manage this situation is with the administration of
- adenosine
- diltiazem
- esmolol
- lidocaine
- flecainide
- In a patient suffering from angina of effort, nitroglycerin may be given sublingually because this mode of administration
- bypasses the coronary circulation
- causes less reflex tachycardia than oral administration
- improves patient compliance
- has a decreased tendency to cause methemoglobinemia
- avoids first-pass hepatic metabolism