CVS Pharmacology module No. 1

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  1. Which one of the following drugs is associated with the development of a lupus-like syndrome, especially in patients identified as “slow acetylators”?
  2. Arniodarone
  3. Clonidine
  4. Nitroglycerin
  5. Procainamide
  6. Terazosin
  1. Which one of the following actions is characteristic of amiloride?
  2. Alkalosis
  3. Block of Na reabsorption in the proximal tubule
  4. Hyperkalemia
  5. Increased tubular reabsorption of Ca
  6. Bicarbonaturia
  1. The most common manifestation of lidocaine toxicity is
  2. CNS dysfunction
  3. drug fever
  4. hypertension
  5. hypokalemia
  6. torsade
  1. A patient with hyperthyroidism develops a cardiac arrhythmia. Optimal treatment of the patient should include management with
  2. amiodarone
  3. bretylium
  4. digoxin
  5. lidocaine
  6. propranolol
  1. Calcium channel antagonists
  2. increase intracellular CAMP
  3. decrease myocardial contractility
  4. increase reactivation of Na channels
  5. decrease intracellular K
  6. increase conduction velocity
  1. In terms of the ability of drugs like digoxin to increase cardiac contractility, their primary action on cardiac cells is
  1. activation of adenylyl cyclase
  2. inactivation of Na channels
  3. activation of the slow Ca channel
  4. inhibition of NaIK-ATPase
  5. activation of the NaIC1 cotransporter
  1. Which one of the following drugs is most likely to block K+ channels in the heart responsible for the delayed rectifier current?
  2. Amiodarone
  3. Encainide
  4. Lidocaine
  5. Phenytoin
  6. Verapamil
  1. The treatment of hyperlipidemic patients with nicotinic acid (niacin) results in
  2. increases in VLDL
  3. decreases in both plasma cholesterol and TGs
  4. inhibition of HMG-CoA reductase
  5. decreases in HDL
  6. no change in total cholesterol in the plasma
  1. Following a myocardial infarction, a patient in the emergency room of a hospital develops ventricular tachycardia. The best way to manage this situation is with the administration of
  2. adenosine
  3. diltiazem
  4. esmolol
  5. lidocaine
  6. flecainide
  1. In a patient suffering from angina of effort, nitroglycerin may be given sublingually because this mode of administration
  2. bypasses the coronary circulation
  3. causes less reflex tachycardia than oral administration
  4. improves patient compliance
  5. has a decreased tendency to cause methemoglobinemia
  6. avoids first-pass hepatic metabolism
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Dr. Ahmed Hafez
CEO & Founder of MEDICINE21 corporation

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