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What is adrenal fatigue? Adrenal fatigue is a term used by alternative health practitioners to explain tiredness and other symptoms which are thought to be due to chronic (long-term) exposure to stressful situations. However, it currently is not a recognised medical diagnosis. Many studies have failed to prove that adrenal fatigue is a medical condition. Adrenal insufficiency Your adrenal glands sit on top of each kidney. Their role is to produce hormones, including adrenaline and noradrenaline. These hormones prepare your body for fight or flight. Adrenal insufficiency (also called Addison’s disease), is a recognised medical condition when your adrenal glands don’t make enough